Patients who acquire pressure ulcers during their hospitalizations incur higher costs of care and treatment, increases in length-of-stay (LOS), additional morbid complications, and decreases in quality-of-life. The occurrence of pressure ulcers among hospitalized patients is considered a sensitive indicator of quality nursing care. Experts assert that quality nursing interventions are paramount in order to prevent and expeditiously treat pressure ulcers. The purpose of this study was to determine whether or not implementing a pressure ulcer educational intervention among nursing staff members on an inpatient orthopedics unit would result in improved staff knowledge of pressure ulcer prevention and treatment, improved staff self-assessed attitudes towards pressure ulcer prevention and treatment, a decreased incidence of inpatient pressure ulcers, and decreased costs. Results were ascertained by comparing pre-intervention and post-intervention unit pressure ulcer incidence rates and costs, and by comparing staff self-assessed pressure ulcer knowledge and attitudes via pre-test and post-test surveys. Both the incidence and overall severity of agency-acquired pressure ulcers dropped from pre-intervention to post-intervention. Although general unit-based patient acuity levels were higher during the post-intervention period, direct nursing care hours were less. Total costs of hospitalization incurred by patients with pressure ulcers were higher during the pre-intervention period, as was the average LOS. While staff pressure ulcer knowledge did not demonstrate statistically significant improvement from pre-intervention to post-intervention, staff attitudes regarding their ability to effectively prevent and treat pressure ulcers improved. Providing ongoing education to nursing staff with advanced wound care experts is an easily replicable and cost-effective means to contain costs and assure quality care.