To be prepared to provide optimal psychosocial and clinical care to a woman affected by cervical cancer, the WOC Nurse must understand the disease and interventions taken at all stages of the disease process. Cervical cancer is the second most common cancer affecting women worldwide. In the U.S. 11,150 new cases are expected to be diagnosed, and nearly 3700 women are expected to die in 2007. Widespread use of Pap screening has decreased incidence since the mid-1950s. Screening detects pre-invasive cervical lesions more frequently than invasive cancer. In fact, the 5-year survival rate for women with pre-invasive lesions is close to 100%. Most cervical pre-cancers develop slowly, increasing the odds of preventing disease in those women who are regularly screened. Survival decreases in advanced disease; overall 5-year survival is 73%. Infection with certain types of human papillomavirus (HPV) is the primary cause of cervical cancer. Infection with oncogenic HPV is necessary but insufficient for the pathogenesis of cancer. Infections are common in healthy women and rarely result in cervical cancer. Progression to cancer is influenced by factors such as immunosuppression, high parity, smoking, and nutritional factors. Treatment depends on stage of disease. Pre-invasive lesions are treated by electrocoagulation, cryotherapy, laser ablation, or local excision. Invasive cancers are treated with surgery, radiation, or both, as well as with chemotherapy. Recurrent disease can be especially challenging as options are limited. The WOC Nurse may first encounter the patient as she is prepared for a urinary and/or fecal diversion or for radiation-induced perineal skin breakdown. This poster will illustrate the areas of impact that nurses have in prevention – use of vaccines, screening – for early detection, treatment, symptom control, education, sexuality intervention, and emotional support required by a woman affected by cervical cancer.