Young adult male farmer in Ghana, West Africa, had a dramatically distended painful abscess between the right thumb and forefinger. Abscess was treated by a shaman for three weeks with herbal poultices. Foul brown exudate was draining from a small hole in the skin. Removal of non-viable tissue revealed a 5cm x 5 cm x 0.5cm deep open wound with a 3cm x 6cm pus-filled pocket created by the accumulated exudate separating the muscle fascia. Keeping dressings in good contact with the woundbed was problematic in this flexible location. Keeping the woundbed moist was challenging due to low humidity. The dressing also needed to be able to absorb the inevitable bleeding which would occur when patient's hand was extended. Flexible polymeric membrane dressings have demonstrated ability to reduce wound pain and inhibit infection while donating or absorbing moisture as needed. Silver has additional anti-infective properties. Therefore, standard and silver polymeric membrane dressings were initiated. Treatment included prayer, an initial antibiotic IM followed by a course of oral antibiotics and direct wound care. After thorough flushing with concentrated salt solution, the caregiver slid a thin layer of silver polymeric membrane filler between the separated layers of muscle. Three days of this treatment cleaned the undermined area well, so a pressure dressing was applied and the fascia layers sealed shut. Plain polymeric membrane dressings were initiated over the remainder of the wound and were changed daily while the silver filler was used, and then three times per week. After the undermined area sealed no woundbed cleansing was needed. Granulation tissue formed quickly. Woundbed remained free of infection and wound was completely closed in 8 weeks. Polymeric membrane dressings provided effective wound management for a large abscess with deep undermining from initiation of treatment to complete closure.