Objective: To determine the relative delivery efficiency and user preference for spray and ointment formulations containing papain, urea, and chlorophyllin copper complex sodium (papain/urea/CCC). Methods: Participants applied both spray (Panafil® Spray) and ointment formulations (Panafil® Ointment, Ziox®, or Gladase-C®) of papain/urea/CCC to identical wound models. The average amount of product used per application was determined by weighing the bottle or tube before the study and after study completion. Each participant was also asked to fill out a questionnaire regarding their preferences for the two formulations. Results: The amount of product used per wound application was 30% less with the spray formulation; resulting in 29% more wound applications per container. The overwhelming majority of study participants found the spray easier and quicker to use than the ointments, and agreed that the spray formulation could reduce the potential for contamination or disruption of the wound bed. Conclusions: The spray formulation of papain/urea/CCC resulted in less product use per wound application than did three different ointment formulations. Participants expressed an overwhelmingly favorable impression of the practical benefits of the spray formulation and its ability to help reduce the risk of wound contamination. Overall, the majority preferred the spray over the ointments.