Pain is frequently mentioned as one of the most important features that impact on quality of life (QOL) of people with chronic venous ulcers. This study aims to analyze and correlate the characteristics of pain and quality of life in patients with chronic venous ulcers. This is an exploratory, cross sectional and descriptive study carried out in two Outpatient Care Centers in São Paulo, Brazil. Methodology: forty adult outpatients, mainly women (65%), aged 67 ± 11 years, who consented to participate in the study were interviewed about their wound pain and QOL through McGill Pain Questionnaire (short version) and WHOQOL-bref, both adapted and validated for Brazilian culture, besides 0 to 10 numerical pain rating scale. WHOQOL-bref showed satisfactory internal consistence for this study (Cronbach alpha = 0.81 for all domains and from 0.45 to 0.85 for each domain). Data were analyzed through parametric and no parametric tests (t-Student, Mann-Whitney and Kruskall Wallis), Pearson and Spearman correlation tests and ANOVA. The results showed an average worst pain score of 6.2 ± 3.5; evaluative and sensitive pain descriptors were most frequents (43.7% and 40.6% respectively). QOL scores varied from 57.6 ± 21.4 to 73.3 ± 19.4, obtaining Physical and Social Relations domains the lower scores. Patients with mild pain level showed lower QOL scores (p<0.01; p<0.02 respectively). There were statistical significant negative and moderate correlations between pain and Physical and Environment QOL domains (p<0.05). Number of times that patients had the venous ulcer variable correlated to evaluative pain dimension, Physical and Environment domains and pain intensity (p<0.02). Only the number of times that patients had the venous ulcer remained as QOL predictor for Physical and Environment domains after logistic regression (p<0.03). Inconclusion, the study contributes to a better understanding of the relations between pain and QOL in venous ulcer patients.