HOFA is a technology based on the introduction or saturation of peroxides into fatty acid esters via the presence of ultraviolet light and controlled temperatures. During the manufacturing process, oxygen is introduced by bubbling oxygen through natural oils at a specific temperature over time until the oil viscosity increases and the peroxide value is achieved. The use of this product has been adopted as a method of preventing pressure ulcers and treating circulatory insufficiencies. It is felt that this therapy is effective due to the release of free oxygen thus promoting microcirculation at the site of application. The purpose of this study was to investigate the effects of HOFA on skin physiology such as local microcirculation, barrier properties & moisturization levels. Microcirculation was evaluated via Laser Doppler, Transepidermal Water Loss (TEWL) was evaluated via Servo Med EP2 Evaporimeter and Moisturization Value was evaluated via Nova DPM 9003. The results indicated a microcirculation increase of 28% microcirculation after application of HOFA to the skin. A reduction in the TEWL after application of HOFA to skin was also observed. An increase Moisturization Value after application HOFA to skin.. Note: all data were generated against a control of no HOFA treatment. Based upon a preliminary evaluation of the HOFA technology/therapy, data shows evidence of a physical response to the application of HOFA to the skin. As a result, an increase in microcirculation, moisturization and a reduction of TEWL were noticed after application. This investigation opens opportunities to further study the benefit of this technology/therapy as a potential pressure ulcer prevention therapy as well as a therapy to improve the barrier properties of the skin.