ABSTRACTS Any process designed to restore the stratum corneum capacity to keep humidity is called moisturizing process. Moisturizing lotions or creams are effective treatments for the dry skin. A good moisturizing product provides both humectants to offset the loss of natural moisture and lipids to provide for those lost in the intracellular layers of the stratum corneum. In Brazil, many people have used essential fatty acids to restore skin moisture and thus prevent the development of pressure ulcers, where the most used is the linoleic acid, which needs to be used on the integral skin Skin protector was initially used in patients who had stomas condition. Today, its use has expanded to prevent dermatitis, especially the one arising from the use of diaper and urinary and anal incontinency, to prevent pressure ulcers as it reduces the effects from friction10 and also to protect the fragile skin under tapes and adhesive dressings, peri wound skin, acting as an interface between the skin and irritating and adhesive products. Currently have been observed an increase of Perineal Dermatitis and Skin damage on peri wound and ostomy Skin. Due the cost, the product used to prevent it is Zinc Oxide paste. The aim of the present study was investigate a clinical performance between Zinc Oxide paste and Skin sealant for Prevention of Skin damage on wet skin. This study was designed as a controlled study. Patients were treated until complete wound healing. Were Included on it study Adults, Elders and Infant patients.. After 02 weeks of treatment was observed in the Skin Sealant group a decrease of Skin damage As conclusion, the skin sealant was effective in 90% of the cases.