Case Descriptions: This case series reports on clinical experience using noncontact, low-frequency ultrasound to promote healing in 3 consenting patients. Patient #1 is an 81-year-old female with a transmetatarsal amputation wound that did not respond to the standard of care for one year. The wound contained heavy yellow slough and her physician expected another amputation. Ninety percent granulation was achieved after 5 months of noncontact ultrasound 2-3 times/week. Full granulation and near-complete closure were achieved 7.5 months later. Patient #2 is a 72-year-old man who was burned on the right hand with scalding water from a tea kettle. The burn was treated with noncontact ultrasound 3 times/week and dressed with silver sulfadiazine and gauze. The wound healed in less than 3 weeks with almost no scarring. Patient #3 is a 50-year-old female who was burned on her anterior torso by scalding water while cooking. After 1-week of dressing with silver sulfadiazine, hydrophilic polyurethane membrane matrix and compression bandage, the wound had developed thick oozing slough. After 1 week of noncontact ultrasound therapy, the slough was resolved and complete granulation was achieved. Three days later, the wound was near full closure with very little scarring. All three patients reported noticeable reductions in pain scores after starting noncontact ultrasound therapy.

 Discussion: In this case series, noncontact ultrasound therapy appears to have stimulated the healing process and alleviated pain in surgical trauma and burn wounds.