Aims: to evaluate the Braden scale's prediction value in hospitalized patients by determining the best cut-off score that indicates the risk of developing pressure ulcer. Methods: a prospective cohort study took place in a private general hospital with 220 beds divided among 13 hospitalization units of different specialties. Most of the patients attended by the hospital are of surgical nature and its average occupation rate is 7.4 days. Firstly the project was approved by Hospital Ethics Committee. The 6-month-period study was conducted with hospitalized adult patients with Braden score ≤18. All of them accepted to participate in the study. After consent patients were submitted to data collecting through alternate daily body examination and Braden scale assessment. During the hospitalization period, each patient was examined at least tree times to be considered for analysis. The data were submitted to sensitivity and specificity analysis through ROC curve and positive (+LR) and negative likelihood ratios (-LR). Results: Most of the 98 patients who composed the sample of the study aged > 71 years old (63.3%). The cut-off scores in the 1^st, 2^nd and 3^rd examinations were 11, 13 and 13 respectively. Sensitivity percentages were 42.6%, 85.7% and 85.7% and for specificity they were 79.1%, 57.1% and 65.9% respectively. Areas under ROC revealed very good accuracy for the cut-off score at first evaluation (64/ CI95% 34 - 94) and good accuracy for the scores ate second and third evaluations (69/ CI95% 33 – 100; and 76/ CI95% 31 – 100 respectively). The results also showed probabilities of 14%, 13% and 16% for the development of pressure ulcers when the tests were positive (+LR) and 2%, 2% and 5% for negative tests (-LR) respectively for the first, second and third evaluations. Conclusion: The Braden scale showed good performance for pressure ulcer prediction for hospitalized patients with cut-off scores of 11 and 13 at three first evaluations.