The WOCN Society 40th Annual Conference (June 21-25th, 2008)


2419

Cell Proliferation Induction (CPIŽ) Wound Therapy in Long-Term Care Settings: An Effective Therapy For Elderly Patients with Stage IV Pressure Ulcers

Richard A. Isenberg, MD, FAPWCA, Regenesis Biomedical, Inc, Vice President, Clinical & Regulatory Affairs and Medical Director, 1435 N. Hayden Rd, Scottsdale, AZ 85257

Rationale: Stage IV pressure ulcers cause significant morbidity and pose major management challenges, especially in long-term care settings.  This study evaluates the effectiveness of Cell Proliferation Induction (CPI)*, a novel Radio Frequency energy treatment modality, in the healing of Stage IV Pressure Ulcers in long-term and extended care settings.  CPI has been shown previously to induce and accelerate cell proliferation in vitro. Methods:  This is an open-label case series at 36 Skilled Nursing Facilities (SNFs), LTACH and nursing homes.    Data collected included subject age, gender, wound type, location, and dimensions.  Subjects were treated with CPI for 3 to 8 weeks.  All subjects received CPI therapy as an adjunct to standard institutional wound care protocols.  This study is a subset of an on-going case series involving multiple wound types, 65 centers and 273 patients. Results:  86 Stage IV Pressure Ulcers were studied.  Among these, 24 were treated with CPI for 3 weeks and 57 were treated for 4 weeks or more. Most patients were residents of skilled nursing facilities (60%) or long term acute care hospitals (30%).  The mean age was 68.3 years.  Wounds were large, with mean initial wound area of 49.9 cm2, and chronic, with mean wound age of 9.9 months.  In the first month of CPI therapy, the percentage of Stage IV wounds which closed was 3.5% and the percentage which reduced in surface area by >50% was 42%.  Overall, Stage IV Pressure Ulcers reduced an average of 31.5% in surface area during the first month of CPI treatment, with a healing rate of 56.3 mm2/day.

Conclusions: CPI therapy promotes the healing of chronic Stage IV Pressure Ulcers in elderly patients in long-term care settings, contributing to a significant reduction in wound size in the first 4 weeks of treatment.


* PROVANT Wound Therapy System (Regenesis Biomedical, Inc., Scottsdale AZ)


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