Total contact casting has been considered the gold standard for offloading Diabetic Neuropathic Foot Ulcers. Typical dressing material for moist wound healing applied under a contact cast has been petroleum gauze as it will maintain that environment for the length of the cast application. A new dressing material is available that may influence healing by its unique ability to manage moisture while maintaining an optimal wound environment. The High Moisture Transpiration Rate of this material creates a negative pressure effect of 200-300 milli torr at the wound surface, 100 milli torr of negative pressure is enough to activate wound fibroblasts. This unique and important aspect of this particular material may stimulate wound fibroblasts and bring about accelerated healing. The fact that the dressing material can stay in place for up to 30 days makes it an attractive choice for use in longer term applications like contact cast application. The ability to combine actives with the dressing as it forms allows for a customized approach to wound healing. Cadexomer iodine and becalpermin have been combined with this material at the time of application in order to manage Wagner Grade 2 Diabetic Foot Ulcers. This presentation discusses the use of this new wound dressing technology in conjunction with the use of "gold standard" contact cast offloading in treating Diabetic Wagner Grade 2 Neuropathic Foot Ulcers.