Extracellular Matrix in an Infant with Oomphalocele

Extracellular Matrix in an Infant with Oomphalocele. Authors: Linda Neiswender RN, BSN, CPN Little evidence exists regarding the use of extracellular matrix in infants. In this case, a 42 day-old infant had closure of a giant oomphalocele with a large porcine dermal collagen patch following serial surgeries for silo reduction. Negative pressure wound therapy (NPWT) was initiated over the patch. At day of life (DOL) 128, minimal granulation had occurred over the patch and it was decided to implement a collagen dressing in the treatment. A collagen microscaffold wound dressing was placed over the patch, covered with a petrolatum gauze non-adherent dressing, and NPWT. Two days following this application granulation tissue was evident in 10% of the wound bed. An extracellular matrix dressing was implemented at this time rather than the collagen microscaffold. At DOL 170 the patient had 100% granulation and physicians were able to place a split-thickness skin graft over the defect.