The Impact of Autologous Platelet Rich Plasma Gel on Chronic Wounds

Purpose: The purpose of this abstract is to demonstrate that using autologous Platelet Rich Plasma Gel (PRP Gel) to treat chronic wounds can reverse the long duration of non-healing to a wound with rapid reduction of area, volume, undermining, sinus tracts and tunneling.  

Methodology: Patient age, albumin, hemoglobin, previous wound duration, and objective wound measurements were prospectively gathered to determine wound area, volume, amount of undermining, sinus tracts & tunneling (ST/T) while being treated with the autologous platelet rich plasma gel* (PRP Gel). PRP Gel contains the patient’s growth factors, cytokines, and chemokines for cell growth and migration, plasma-derived proteins to produce a fibrin matrix scaffold and anti-inflammatory properties to progress the natural healing process.  

Results: Two hundred (200) patients with 285 wounds were treated in 39 sites. Wound etiology included: 32 venous ulcers, 41 diabetic ulcers, 89 pressure ulcers, 38 surgical/trauma wounds, 2 arterial wounds, 24 wound dehiscence, 5 other wounds, and 1 sickle cell wound. The mean patient age was 59.6 years and previous wound duration was 48.2 weeks.

All the following data reflects the mean outcomes. In 2.2 treatments over 2.8 weeks, 90.5% of wounds decreased 63.6% in volume, 86.3% of the wounds reduced 47.5% in area. 89.4% (59/66) of the wounds with undermining reduced 71.9% in 2.8 treatments over 2.2 weeks. 85.7% (24/28) of the wounds with sinus tracts/tunneling had a mean reduction of 49.3% in 2.5 treatments over 1.8 weeks.

Conclusion: PRP Gel initiated rapid size reduction in long-standing non-healing wounds of multiple etiologies in multiple sites.

 * AutoloGel™, Cytomedix, Inc, Rockville, MD