Purpose: The purpose of this study were to investigate incidence of medical devices related pressure ulcers(MDRPU) , and to compare the differences in the demographic and wound characteristics among MDRPUs and non-MDRPUs patients. Methods: A prospective cohort study design was used. From January 2013 to December 2013, all hospitalized patients in a 1000-bed medical center were inspected the patients' skin daily by registered nurses. Data were collected by two WOCN using structure questionnaires that included demographics and wound status assessment tool. Means, standard deviations, and percentages were used for descriptive purposes. Chi-square test and independent t test were used for dichotomous variables and continuous variables, respectively. Results: Of the total 21,101 patients, 529 (2.5%) patients developed PUs during hospitalized. The proportion of patients with medical devices related PUs was 27.41% (145 of 529) and the incidence was 0.7 % (145 of 21101). Majority of MDRPUs (59.8%) occurred on the face, head, and neck. 48% MDRPU were related to respiratory medical device. Most (49.5%) of MDRPUs involved the stage II. The mean number of days for wound occurred was 12 (SD=11.5). The significant variables (p< .05) of difference in MDRPUs and non- MDRPU were location, classification, and division. Conclusion: The results of this study provide an outline of MDRPUs that can be used in developing preventive strategies for MDRPUs. They can be also be used as a reference for skin tears care curriculum in continuing nursing education.