Enteroatmospheric fistulas (EAFs) are a common complication of open abdomen bowel surgery with an estimated 2%-50% of patients developing fistulas post surgery.1 The presence of an EAF increases patient morbidity and provides a challenge to the wound care team.2 Traditionally, management of EAFs has involved placing large fistula management pouches over the wound to collect and contain effluent. However, more recent techniques isolate the fistula and apply negative pressure wound therapy (NPWT) to the rest of the wound.2;3 We isolated an EAF and applied NPWT to a large abdominal wound to promote granulation tissue formation, and decrease wound dimensions. A fistula management pouch was utilized for several months to encompass the wound and contain effluent. This method proved to be ineffective. The fistula was then isolated utilizing a collapsible EAF isolation device and an ostomy appliance to contain effluent. The wound was then managed with NPWT. Closed incision negative pressure therapy (ciNPT) was used for 5 days following abdominal wall reconstruction. A 54-year-old morbidly obese female was admitted with a small bowel obstruction and large ventral hernia. The patient underwent an exploratory laparotomy with lysis of adhesions and ventral hernia repair with mesh placement, and she ultimately developed an EAF. Contraction of wound edges and presence of granulation tissue were observed after NPWT use in the wound bed around the isolated EAF. At 7 months after presentation, the patient underwent abdominal wall reconstruction and closure followed by 5 days of post operative ciNPT. The patient was successfully discharged to home under the care of visiting nurses. The application of the collapsible EAF isolation and effluent containment devices in conjunction with NPWT produced positive patient outcomes, including patient satisfaction, decreased financial burden, promotion of wound healing, and ultimately wound closure.