For this process improvement project, 30 ICU patients with fecal incontinence were selected for evaluation. All standard skin care and pressure ulcer prevention protocols were maintained for all patients. The skin was evaluated for breakdown daily. The number of applications and ampules used were also recorded. All skin injuries were evaluated, including MASD, pressure injuries, and shearing injuries. Overall, the cyanoacrylate skin protectant helped maintain the integrity of the at-risk skin, and skin breakdown was limited. This is a beneficial option for ICU patients with fecal incontinence to prevent breakdown since a sacral foam bordered dressing cannot be maintained in patients with fecal incontinence.