Targeted topical biofilm disruption therapy for complex wounds: A Limited Patient Case Series

TITLE: Targeted topical biofilm disruption therapy for complex wounds: A Limited Case Study

INTRODUCTION:

Wound healing is a complex problem.  Patient’s that have biofilm formed in the base of the wound is a common occurrence with chronic wound care patients and is known to stall healing.  Further, the risk of progressive infections is especially high among patients with serious comorbid conditions and wounds that involve biofilm.   Research has revealed that delayed healing may be due to a self-sustaining biofilm matrix on the wound bed which is present in over 90% of chronic wounds. Unchecked or untreated, biofilm impairs wound healing through induced chronic inflammation, which leads to biofilm-based infection, and protects the bacteria within the matrix from even the most robust external attack.  Expert opinion now supports a new perspective toward biofilm directed interventions that disrupts the protective biofilm matrix. Use of biofilm disrupting technology is crucial as an early adjunctive treatment option for chronic wounds.

OBJECTIVE:

This is a case series report of the authors’ experience with the use of a biofilm disrupting gel on complex wounds placed on chronic wound patients.

MATERIALS AND METHODS:

Patients were selected who were unresponsive to standard wound care (no reduction in wound surface area for >4 weeks), had failed to respond to aggressive debridement, unresponsive to antimicrobial dressings, had inadequate granulation tissue, and were not candidates for an advanced therapeutics. The biofilm disrupting gel was provided with various dressings as well as any appropriate off loading, and nutritional supplementation.

RESULTS:

Patients applied the biofilm disrupting gel at regular dressing changes ranging from daily to weekly and were followed at regular intervals (weekly).

CONCLUSION:

Despite having failed numerous prior therapies, patients on the biofilm disrupting gel had a decrease in slough, an increase in granulation tissue and, epithelialization.