Purpose: The purpose of the study is to determine the efficacy of using skin temperature as a surrogate measure for the thermoregulatory function of the skin to predict pressure ulcer risk. Theoretical/Conceptual Framework: Tissue tolerance to pressure is a risk factor for pressure ulcer development (Braden & Bergstrom, 1987). Skin temperature, as a surrogate for blood flow and related to tissue tolerance, is a measurement of the heat conducted by capillaries to the skin reflecting the thermoregulatory function of the skin. Measured over several scales in a time series, entropy characterizes the degree of irregularity or randomness in the temperature signal. Lower values are associated with frailty. Subjects: A convenience sample of 16 nursing facility residents, 71 – 97 years old, female (10), White (13), 9 at high (score < 13), and 7 at low or no risk (score > 14) for pressure ulcers using the Braden Scale for Pressure Sore Risk© were enrolled. Method: Skin temperature was measured continuously for 88 hours using a skin temperature thermistor (Series 2000 Mini-Logger Model 192-2000-00 ML 2000, MiniMitter, Bend, OR). Multiscale entropy was computed to characterize the degree of irregularity in skin temperature. Data were analyzed using Matlab 14.0 and SPSS 11.5. Results: There was a significant difference in the mean multiscale entropy for skin temperature when averaged over all scales between nursing facility residents at high or low risk for pressure ulcers, ANOVA F(1, 14) = 4.74, p = .05. Although not statistically significant (p = .64), multiscale entropy for temperature was lower at all scales in residents who developed pressure ulcers (n = 2). Conclusions: Skin temperature as a surrogate for the thermoregulatory function of the skin differentiated between risk categories and pressure ulcer outcomes providing preliminary evidence for a larger trial to enhance our understanding of pressure ulcer risk.