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Purpose
The goal of this case study is to evaluate clinical efficacy when using bFGF after NPWT in various complicated pressure ulcers and emphasize the importance of the optimal time point to make a proper environment for wound healing regarding using bFGF after NPWT.
Background
Pressure ulcers are a medical challenge to the health care system and require a meticulous multidisciplinary approach to treat their complications (i.e wound infection, long-term hospitalization). Management of pressure ulcers needs strategies for treatment includes accurate assessment of pain and nutritional status, relieving pressure, maintaining a moist wound environment, encouraging granulation and epithelial tissue formation, evaluating the need for debridement, and controlling infection There are crucial risk factors that cause aggravated wound conditions, such as age, use of immunosuppressants of post-transplantation, and chronic infected wounds. bFGF and applying NPWT as a delivery system to accelerate the wound healing process have been available to the above patients with pressure ulcers. According to the WOCN clinical practice guidelines the consideration of adjunctive therapies such as topical negative pressure and growth factors are mentioned to enhance the healing of recalcitrant Stage III and IV wounds.
Method and Results
To apply to bFGF, necrotic debridement was performed first and NPWT was applied after controlling infection in all 4 cases.
All cases with pressures ulcer have decreased in the affected area. Case 1 had a coccyx pressure ulcer with chronic respiratory failure and amyotrophic lateral sclerosis. Case 2 had a sacrum pressure ulcer with the improved wound healing process. It decreased 68.1%, so there was a 50% decreased in the area. Case 3 had a skin graft and Case 4 had a liver transplantation with a coccyx pressure ulcer with tunneling. Both cases had been improving
Conclusions
Through the case studies, we concluded that bFGF could be used to accelerate healing in chronic pressure ulcers after NPWT as a suitable topical treatment. Although many research have demonstrated the cost effect and improved wound healing regarding the use of bFGF and NPWT in the field of wound treatment, research about pressure ulcers are very limited. Further research about the optimal time points and clinical efficacy regarding the use of bFGF after NPWT development of a coordinated protocol to improve the wound healing process are required.
The goal of this case study is to evaluate clinical efficacy when using bFGF after NPWT in various complicated pressure ulcers and emphasize the importance of the optimal time point to make a proper environment for wound healing regarding using bFGF after NPWT.
Background
Pressure ulcers are a medical challenge to the health care system and require a meticulous multidisciplinary approach to treat their complications (i.e wound infection, long-term hospitalization). Management of pressure ulcers needs strategies for treatment includes accurate assessment of pain and nutritional status, relieving pressure, maintaining a moist wound environment, encouraging granulation and epithelial tissue formation, evaluating the need for debridement, and controlling infection There are crucial risk factors that cause aggravated wound conditions, such as age, use of immunosuppressants of post-transplantation, and chronic infected wounds. bFGF and applying NPWT as a delivery system to accelerate the wound healing process have been available to the above patients with pressure ulcers. According to the WOCN clinical practice guidelines the consideration of adjunctive therapies such as topical negative pressure and growth factors are mentioned to enhance the healing of recalcitrant Stage III and IV wounds.
Method and Results
To apply to bFGF, necrotic debridement was performed first and NPWT was applied after controlling infection in all 4 cases.
All cases with pressures ulcer have decreased in the affected area. Case 1 had a coccyx pressure ulcer with chronic respiratory failure and amyotrophic lateral sclerosis. Case 2 had a sacrum pressure ulcer with the improved wound healing process. It decreased 68.1%, so there was a 50% decreased in the area. Case 3 had a skin graft and Case 4 had a liver transplantation with a coccyx pressure ulcer with tunneling. Both cases had been improving
Conclusions
Through the case studies, we concluded that bFGF could be used to accelerate healing in chronic pressure ulcers after NPWT as a suitable topical treatment. Although many research have demonstrated the cost effect and improved wound healing regarding the use of bFGF and NPWT in the field of wound treatment, research about pressure ulcers are very limited. Further research about the optimal time points and clinical efficacy regarding the use of bFGF after NPWT development of a coordinated protocol to improve the wound healing process are required.