Pemphigus is a rare autoimmune disease with bullae formation affecting mucous membranes. The incidence is 0.5-3.2 patients per million persons each year. Skin eruption is a common clinical symptom and also a challenge to nursing wound management. We reported a 41 year-old woman with pemphigus and associated bullae formation and ulceration over her face, nose and ears. Despite treatment with steroid ointment for months, her wound deteriorated. The patient suffered from pain, insomnia, anxiety and self image change. A recurrent crust of yellow secretion and pain after fissuring of dry skin made it difficult to manage her wounds. By using Omiderm® to cover her wound we were able to reduce the nursing intervention time from 2 hours to 30mins. After treatment for 10 days, her wound condition improved significantly and she was discharged with self care of wound. After 20 days, her wound recovered completely. Nursing wound management with Omiderm® can save the time of dressing change, decrease pain and promote healing. Additionally, it may raise the confidence of patients to our treatment and increase the patient’s social activities.