The Impact of Autologous Platelet Rich Plasma Gel on Rapid Wound Improvement in the Outpatient Setting

Purpose: The purpose of this abstract is to demonstrate that using autologous Platelet Rich Plasma Gel to treat chronic wounds can reverse the long duration of non-healing to a wound with rapid reduction of area, volume, undermining, sinus tracts and tunneling.  

Methodology: Patient age, albumin, hemoglobin, previous wound duration, and objective wound measurements were prospectively gathered to determine wound area, volume, amount of undermining, sinus tracts & tunneling (ST/T) while being treated with the autologous platelet rich plasma gel* (PRP Gel). PRP Gel contains the patient’s growth factors, cytokines, and chemokines for cell growth and migration, plasma-derived proteins to produce a fibrin matrix scaffold and anti-inflammatory properties to progress the natural healing process.  

Results: Twenty seven patients with 34 wounds were treated in 3 outpatient clinics. Wound etiology included: 12 venous ulcers, 11 diabetic ulcers, 4 pressure ulcers, 2 trauma wounds, 2 arterial wounds, 2 wound dehiscence, and 1 sickle cell wound. The mean patient age was 61.4 years and previous wound duration was 56.7 weeks. All the following data reflects the mean outcomes. In 3.2 treatments over 3.5 weeks, 91.2% of wounds decreased 66.7% in volume, 91.2% of the wounds reduced 52.7% in area. 100% of the wounds with undermining, sinus tracts or tunneling responded positively. Wounds with undermining (8/34 or 24%) had a mean reduction of 95% in 2.5 treatments over 2.9 weeks. Wounds with sinus tracts/tunneling (2/34 or 6%) had a mean reduction of 7.3% in 3 treatments over 1.3 weeks.

Conclusion: Rapid size reduction in long standing wounds utilizing PRP Gel allowed the outpatient clinic to achieve their goal of progressing healing at a faster rate than the patients had experienced previously.