Methodology: This two-phase project uses retrospective case-control data with cases (patients who developed HPU) and controls (patients who did not) selected at the ratio of 1:2, respectively. Research and literature review revealed 13 factors that appear to influence HPU development: Diabetes, Vascular , Neuropathy, Braden Scale score 18 or less, 70 years or greater, immobility, perfusion issues, obesity, cachexia, surgery 3 or more hours, ICU stay >3 days, ventilator >3 days, and activity status.
Phase 1 data was collected on 150 patients with HPUs and 300 without. To validate the method in Phase 2, data was collected on 102 patients, 34 with HPUs and 68 without HPUs.
Statistics: Chi-square analysis was used to study the association of each variable with HPUs. Univariate analyses identified patient characteristics and hospital conditions significantly associated with HPUs. These variables were used in a multiple logistic regression modeling to develop a score to identify high-risk patients. ROC curves are currently being used to select the cutpoint for this score with the best overall sensitivity and specificity.
Results: Chi-square analysis in Phase I showed that Vascular disease (OR=4.421, 95% CI, 2.573-7.595, X2=.000), Diabetes (OR=2.557, 95% CI, 1.652-3.958, X2=.000), immobility (OR=16.491, 95% CI, 8.821-30.828, X2=.000), and Braden Scale score (18 or less) (OR=9.5, 95% CI, 5.3,17.2) have a strong influence on HPU development. Phase 2 (validation) analysis is currently being conducted and is demonstrating consistency with Phase I findings.
Conclusion: Targeting certain hospitalized populations who are deemed more at-risk for HPUs, will allow implementation of appropriate prevention measures.